Aurora B helps the central spindle measure up
نویسندگان
چکیده
منابع مشابه
Aurora B helps the central spindle measure up
Aurora B helps the central spindle measure up D uring anaphase, cells assemble a central spindle between the segregating chromosomes. Micro-tubule plus ends overlap in the middle of the cell, creating a spindle midzone that recruits factors involved in positioning the cytokinetic actomyosin ring around the cell equator. Regulating the length and organization of central spindle microtubules is t...
متن کاملAurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A
Anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A. We show that an MKlp2-dependent pool of Aurora B at the central spindle, rather than global Aurora B activity, regulates KIF4A accumulation at the central spindle. KIF4A phosphorylation by Aurora B stimulates the maximal microtubule-dependent ATPase activity of KIF4A and promotes i...
متن کاملAurora B and Kif2A control microtubule length for assembly of a functional central spindle during anaphase
The central spindle is built during anaphase by coupling antiparallel microtubules (MTs) at a central overlap zone, which provides a signaling scaffold for the regulation of cytokinesis. The mechanisms underlying central spindle morphogenesis are still poorly understood. In this paper, we show that the MT depolymerase Kif2A controls the length and alignment of central spindle MTs through depoly...
متن کاملRelocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2
Mitotic kinases of the Polo and Aurora families are key regulators of chromosome segregation and cytokinesis. Here, we have investigated the role of MKlp1 and MKlp2, two vertebrate mitotic kinesins essential for cytokinesis, in the spatial regulation of the Aurora B kinase. Previously, we have demonstrated that MKlp2 recruits Polo-like kinase 1 (Plk1) to the central spindle in anaphase. We now ...
متن کاملKIF4A and PP2A–B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle
The mitotic kinase Aurora B is concentrated at the anaphase central spindle by the kinesin MKlp2 during mitotic exit and cytokinesis. This pool of Aurora B phosphorylates substrates including the kinesin KIF4A to regulate central spindle length. In this paper, we identify a counteracting system in which PP2A-B56γ and -ε, but not PP2A-B56α, -β, and -δ, are maintained at the central spindle by KI...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2013
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2024if